Wednesday, October 29, 2014

Live Long & Prosper Newsletter October 2014

This newsletter was compiled from the latest research on health and longevity, by David Donohue, MD, FACP.

Nutrition
1.   Nutrition and Physical Activity Cancer Prevention Guidelines, Cancer Risk, and Mortality in the Women's Health Initiative.
   Women who followed of the American Cancer Society (ACS) Nutrition and Physical Activity Cancer Prevention Guidelines had 27% lower death rate (and 20% lower rate of death from cancer) than those who did not. What are those recommendations? The usual smattering: "Achieve and maintain a healthy weight throughout life. Be as lean as possible throughout life without being underweight. Avoid excess weight gain at all ages. For those who are overweight or obese, losing even a small amount of weight has health benefits and is a good place to start. Get regular physical activity and limit intake of high-calorie foods and drinks as keys to help maintain a healthy weight. Be physically active. Adults: Get at least 150 minutes of moderate intensity or 75 minutes of vigorous intensity activity each week (or a combination of these), preferably spread throughout the week. Children and teens: Get at least 1 hour of moderate or vigorous intensity activity each day, with vigorous activity on at least 3 days each week. Limit sedentary behavior such as sitting, lying down, watching TV, and other forms of screen-based entertainment. Doing some physical activity above usual activities, no matter what one’s level of activity, can have many health benefits. Eat a healthy diet, with an emphasis on plant foods. Choose foods and drinks in amounts that help you get to and maintain a healthy weight. Limit how much processed meat and red meat you eat. Eat at least 2½ cups of vegetables and fruits each day. Choose whole grains instead of refined grain products. If you drink alcohol, limit your intake. Drink no more than 1 drink per day for women or 2 per day for men."
January 10, 2014

2.   [Metformin, an antidiabetic molecule with anti-cancer properties].
   This study cites evidence that metformin might be cancer preventing. Who? Metformin is the first drug we reach for, when you get diabetes. It is also used in polycystic ovarian disease, in childhood obesity, and it is occasionally used in the prevention of diabetes. Stay tuned, but we might be using more of this drug.
January 17, 2014

3.   Social isolation and adult mortality: the role of chronic inflammation and sex differences.
   We know that people who are socially isolated have more health problems and die younger. This report cites some evidence that social isolation is also associated with some markers of inflammation. Not clear whether social isolation causes inflammation or vice versa.
January 25, 2014

Exercise
1.   Fatalities of pedestrians, bicycle riders, and motorists due to distracted driving motor vehicle crashes in the U.S., 2005-2010.
   True or false? "The era of smart phones has distracted drivers and made the roads less safe for cyclists and pedentrians." True. This study of US motorists found: "The rate of fatalities per 10 billion vehicle miles traveled increased from 116.1 in 2005 to 168.6 in 2010 for pedestrians and from 18.7 in 2005 to 24.6 in 2010 for bicyclists. Pedestrian victims of distracted driving crashes were disproportionately male, 25-64 years of age."
January 8, 2014

2.   Protective role of resting heart rate on all-cause and cardiovascular disease mortality.
   Your doctor makes a big fuss about blood pressure. But who speaks for the ugly step-sister of vital signs, the heart rate? This study finally gives her day. People with resting heart rate under 60 beats per minute do in fact live longer than those with higher heart rates over 80 beats per minute.
January 28, 2014

3.   Exercise in the prevention and rehabilitation of breast cancer.
   " The relative risk reduction of breast cancer for women who engaged in moderate to vigorous physical activity for 3-5 days peek week ranged between 20-40 %. Furthermore, several studies demonstrated a 24-67 % reduction in the risk of total deaths and 50-53 % reduction in the risk of breast cancer deaths in women who are physically active after breast cancer diagnosis compared with sedentary women."
February 6, 2014

Lifestyle
1.   Diet and cancer: Risk factors and epidemiological evidence.
   Based on epidemiologic evidence, "Moderate physical activity after breast cancer diagnosis contributes to 40% reduction of recurrence/disease-specific mortality".
January 1, 2014

2.   Type 2 diabetes and the risk of mortality among patients with prostate cancer
   "Type 2 diabetes was associated with a 23 % increased risk of prostate cancer mortality and a 25 % increased risk in all-cause mortality"
January 2, 2014

3.   DASH and Mediterranean-Type Dietary Patterns to Maintain Cognitive Health
   We have no pill for Alzheimer's Disease, no surgery for dementia. What can we do to prevent it? Regular exercise clearly benefits (both aerobic exercise and strength training). What about diet? This study reviews the literature and finds strong evidence that the DASH Diet, which is similar to the Mediterranean Diet in its emphasis on plant based nutrition, helps significantly.
January 4, 2014


Prevention
1.   Nutrition and Physical Activity Cancer Prevention Guidelines, Cancer Risk, and Mortality in the Women's Health Initiative.
   Women who followed of the American Cancer Society (ACS) Nutrition and Physical Activity Cancer Prevention Guidelines had 27% lower death rate (and 20% lower rate of death from cancer) than those who did not. What are those recommendations? The usual smattering: "Achieve and maintain a healthy weight throughout life. Be as lean as possible throughout life without being underweight. Avoid excess weight gain at all ages. For those who are overweight or obese, losing even a small amount of weight has health benefits and is a good place to start. Get regular physical activity and limit intake of high-calorie foods and drinks as keys to help maintain a healthy weight. Be physically active. Adults: Get at least 150 minutes of moderate intensity or 75 minutes of vigorous intensity activity each week (or a combination of these), preferably spread throughout the week. Children and teens: Get at least 1 hour of moderate or vigorous intensity activity each day, with vigorous activity on at least 3 days each week. Limit sedentary behavior such as sitting, lying down, watching TV, and other forms of screen-based entertainment. Doing some physical activity above usual activities, no matter what one’s level of activity, can have many health benefits. Eat a healthy diet, with an emphasis on plant foods. Choose foods and drinks in amounts that help you get to and maintain a healthy weight. Limit how much processed meat and red meat you eat. Eat at least 2½ cups of vegetables and fruits each day. Choose whole grains instead of refined grain products. If you drink alcohol, limit your intake. Drink no more than 1 drink per day for women or 2 per day for men."
January 10, 2014

2.   Exercise in the prevention and rehabilitation of breast cancer.
   " The relative risk reduction of breast cancer for women who engaged in moderate to vigorous physical activity for 3-5 days peek week ranged between 20-40 %. Furthermore, several studies demonstrated a 24-67 % reduction in the risk of total deaths and 50-53 % reduction in the risk of breast cancer deaths in women who are physically active after breast cancer diagnosis compared with sedentary women."
February 6, 2014

3.   Eight ways to stay healthy after cancer: an evidence-based message.
   There are 12 million cancer survivors in the United States. I see them react in very different ways to a diagnosis of cancer. Naturally, some are irate and react with defiance, continuing to smoke for instance. This report is in line with the American Cancer Society guidelines. It recommends these measures to prolong life and happiness: '(1) don't smoke, (2) avoid secondhand smoke, (3) exercise regularly, (4) avoid weight gain, (5) eat a healthy diet, (6) drink alcohol in moderation, if at all, (7) stay connected with friends, family, and other survivors, (8) get screening tests and go to your regular checkups."
February 7, 2014

Safety
1.   Fatalities of pedestrians, bicycle riders, and motorists due to distracted driving motor vehicle crashes in the U.S., 2005-2010.
   True or false? "The era of smart phones has distracted drivers and made the roads less safe for cyclists and pedestrians." True. This study of US motorists found: "The rate of fatalities per 10 billion vehicle miles traveled increased from 116.1 in 2005 to 168.6 in 2010 for pedestrians and from 18.7 in 2005 to 24.6 in 2010 for bicyclists. Pedestrian victims of distracted driving crashes were disproportionately male, 25-64 years of age."
January 8, 2014

2.   14-year risk of all-cause mortality according to hypoglycaemic drug exposure in a general population.
   An interesting 14 year study of 3300 French diabetics. The researchers controlled for a host of confounding variables, and found that those who took insulin had a death rate almost 5X that of non-diabetics. Whereas those who took metformin along had a death rate of 2.3X relative to non-diabetics. Surprisingly, the best drugs were the sulfonylurea drugs, now out of vogue because or their risk for causing low blood sugar. Diabetics on these drugs had a relative risk of death of 1.7. That is they had only a 70% increased risk of death in any given year, relative to non-diabetics. Of course, who gets put on insulin? It is people with more severe diabetes.
April 23, 2014

Monday, October 13, 2014

Come Run a Charity 5K!

Progressive Health of Delaware is proud to be a sponsor for the HOPE 5K in Arden, DE on Saturday, October 25th at 9.00am.  Come run with Dr. Donohue, Dr. Zarek, and their kids as they support this worthy cause.  See more information about Premiere Charities at 

Temporarily Out of Flu Shots

We are currently out of the high dose flu vaccines for our patients 65 and older.  We expect them to be back in stock next week.  We will update our website when they have arrived.  We do have our regular flu shots available for our patients under 65.  See walk-in schedule on previous post.  Stay well!

Monday, September 22, 2014

Walk in for flu shot!

Our flu clinics are Mondays, Tuesdays, and Thursdays from 9-12 and from 4-5pm. No appointment necessary!

Live Long and Prosper Newsletter September 2014

This newsletter was compiled from the latest research on health and longevity, by David Donohue, MD, FACP.

Nutrition
1.   Therapeutic applications of herbal medicines for cancer patients.
   Well most herbal medicines strike out when subjected to the jaundiced rigour of Evidence-Based Medicine. But there are a few stand-outs. In particular, if I ever get lung cancer or perhaps others, I will start furiously googling "Pan-Asian medicine plus vitamins". One legit appearing study showed impressive results.
August 29, 2013

2.   Dark Chocolate: An Obesity Paradox or a Culprit for Weight Gain?
   Dark chocolate has lots of promising antioxidant phytochemicals that chocolate-loving researchers love to tout and chocolate-loving NIH staffers love to fund. Fortunately, some compelling clinical data point to slight benefits on blood pressure, blood sugar, and weight. I am a fair trade 80-85% cacao junkie myself.
September 5, 2013
Exercise
1.   Low-risk lifestyle, coronary calcium, cardiovascular events, and mortality: results from MESA.
   The more of these you did the lower your death rate: * don't smoke, * maintain a healthy weight, * healthy diet, * regular exercise. What is newish here is that they also found the coronary calcium score correlated with death as well. This is a test you can choose to pay for, as a measure of the plaque in the arteries around the heart. Mounting evidence suggests it can be predictive of your risk for heart disease and death. Of course, a simpler test is to ask yourself how well you are doing with respect to the 4 behaviors above.
September 8, 2013

2.   Usefulness of step counts to predict mortality in Japanese patients with heart failure.
   If you are Japanese and have congestive heart failure (CHF) then walk more than 4,889 steps per day or die!! Well no. Actually you face 2.28 times the risk of death if you are in the group who takes that many steps or less. We can postulate that exercise might reduce death in CHF patients, and it might benefit the rest of us.
September 15, 2013
Lifestyle
1.   Physical activity and other lifestyle factors in relation to the prevalence of colorectal adenoma: a colonoscopy-based study in asymptomatic Koreans
   People who exercise more have half the risk of colon adenomas (nasty pre-cancerous polyps).
August 31, 2013

2.   Depressive symptoms are a risk factor for all-cause mortality: results from a prospective population-based study among 3,080 cancer survivors from the PROFILES registry
   Cancer survivors who get depressed have double the rate of mortality compared with non-depressed cancer survivors.
August 31, 2013
Prevention
1.   Lifestyle and cancer prevention in women: knowledge, perceptions, and compliance with recommended guidelines.
   Study of American women - "Only 9.9% of women who reported eating a healthy diet met minimum fruit and vegetable recommendations; 39.7% of women who reported regular physical activity met the minimum recommendation."
September 27, 2013

2.   High concentrations of a urinary biomarker of polyphenol intake are associated with decreased mortality in older adults.
   People with higher levels of polyphenol in their urine had 30% lower death rate. So add some polyphenols to your urine! You could grind them up and just add to the toilet for lots of healthy toilet goodness. Well assuming there might be an ounce of causation in this relationship, maybe your best strategy is to eat some polyphenols so they end up in your urine. "From whence" you query? Berries, artichokes, coffee, flax meal, dark chocolate, tea, apples.
November 5, 2013
Safety
1.   Touch as an Interpersonal Emotion Regulation Process in Couples' Daily Lives: The Mediating Role of Psychological Intimacy.
   Touching one's boyfriend/girlfriend correlated with better well-being 6 months later. Let that be a lesson to us all.
August 22, 2013

2.   '…I've Found Once the Weight Had Gone Off, I've Had a Few Twinges, But Nothing Like Before'. Exploring Weight and Self-Management of Knee Pain.
   Knee pain very much improves with weight loss.
August 22, 2013

3.   When is acute persistent cough in school-age children and adults whooping cough?
   Do you have an active persistent cough for 2 weeks? According to this New Zealand study, there is a 10% chance you have whooping cough.
August 28, 2013
Personalized Health


   No stories found.
Medication
1.   Heart rate at rest, exercise capacity, and mortality risk in veterans.
   We are familiar with elevated blood pressure being a risk factor for heart disease and stroke and death. But what about the heart rate (number of beats per minute)? It turns out this too is a predictor of cardiovascular disease when elevated. For each increase of resting heart rate of 10 beats per minute, the investigators observed an 11% increase in mortality.
January 8, 2014

2.   Relationship between obesity and obesity-related morbidities weakens with aging.
   Older people have less health benefits from having a lower BMI, than do younger people.
February 5, 2014

Friday, September 5, 2014

Flu Shots Are In!

Our regular and high dose flu shots have now arrived.  Our flu clinics are Mondays, Tuesdays, and Thursdays from 9-12 and from 4-5pm. No appointment necessary during these times. Please stop by!

Friday, August 22, 2014

High Dose Flu Shots Available for 65+

Our high dose flu shots have arrived. This vaccine is for patients over the age of 65, and research has shown it to be more effective in that population than the standard flu shot. 

Please ask us at your office visit if you would like to receive this vaccine. 

Our regular flu vaccines should arrive around September 10th. We will be starting our walk-in flu clinics around September 15th. Stay healthy everyone!

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